Papers / Wissenschaft

Menopause. 2012 Apr;19(4):426–32.

Pomegranate seed oil in women with menopausal symptoms: a prospective randomized, placebo-controlled, double-blinded trial.


Depart­ment of Obstet­rics and Gyne­col­o­gy, Med­ical Uni­ver­si­ty of Vien­na, Vien­na, Aus­tria.



The aim of this study was to inves­ti­gate the poten­tial effects of pome­gran­ate seed oil (PGS) on menopausal symptoms.


The prospec­tive ran­dom­ized, place­bo-con­trolled, dou­ble-blind­ed tri­al was com­plet­ed by 81 post­menopausal women, who received two dai­ly dos­es of either 30 mg PGS con­tain­ing 127 μg of steroidal phy­toe­stro­gens per dose or a place­bo for 12 weeks. The par­tic­i­pants report­ed their num­ber of hot flash­es and com­plet­ed the Menopause Rat­ing Scale II at base­line and at weeks 4, 8, 12, and 24. At base­line and after 12 weeks, hor­mon­al sta­tus was determined.


After 12 weeks of treat­ment, PGS reduced the num­ber of hot flash­es per day by 4.3 (38.7%), where­as place­bo reduced it by 2.5 (25.6%). Both groups were sig­nif­i­cant com­pared with base­line, but the treat­ed group was not sig­nif­i­cant com­pared with the place­bo group (P = 0.17). After 24 weeks, the treat­ed group showed a mean of 7.1 (interquar­tile range, 4.0) hot flash­es per day com­pared with the place­bo group with a mean of 8.8 (interquar­tile range, 5.0; P = 0.02). Although the over­all sum score of the Menopause Rat­ing Scale II para­me­ters at week 12 decreased in the treat­ed group from 16.0 to 9.0 at week 12 and in the place­bo group from 18.0 to 14.5 (P = 0.08), the sum score of the veg­e­ta­tive somat­ic symp­toms sub­group decreased strong­ly ver­sus place­bo (P < 0.03), attrib­ut­able main­ly to an improve­ment in sleep­ing dis­or­ders. PGS did not affect the hor­mone sta­tus, and no adverse effects were reported.


In post­menopausal women, PGS does not sig­nif­i­cant­ly reduce hot flash­es with­in a 12-week obser­va­tion peri­od, but fur­ther stud­ies are need­ed to inves­ti­gate the long-term effect.

[PubMed — in process]